Research Overview
Retatrutide is a triple agonist (GLP-1, GIP, and glucagon). Research interest is once weekly.
This page is the 10 mg vial. Mix: 1.0 mL bacteriostatic water → 10 mg/mL. Same concentration as a 20 mg vial with 2.0 mL or a 30 mg vial with 3.0 mL, so the unit table matches the beginner cheat sheet.
| Parameter | 10 mg research model |
|---|---|
| Vial | 10 mg lyophilized |
| Standard mix | 1.0 mL bacteriostatic water |
| Concentration | 10 mg/mL |
| Easy mark | 5 units = 0.5 mg (1 unit = 100 mcg) |
| Pattern | Once weekly |
| Beginner start | 0.5 mg (or 1 mg) for weeks 1-4 |
Mix Math
Add 1.0 mL bacteriostatic water to the 10 mg vial.
U-100 math at 10 mg/mL: 1 unit = 0.01 mL = 100 mcg.
| Weekly amount | Units | Volume |
|---|---|---|
| 0.5 mg | 5 units | 0.05 mL |
| 1.0 mg | 10 units | 0.10 mL |
| 1.5 mg | 15 units | 0.15 mL |
| 2.0 mg | 20 units | 0.20 mL |
| 2.5 mg | 25 units | 0.25 mL |
| 3.0 mg | 30 units | 0.30 mL |
Mix Steps
- Gather the 10 mg vial, bacteriostatic water, alcohol swabs, and a sterile U-100 syringe.
- Wipe both rubber stoppers with alcohol and let dry.
- Draw 1.0 mL bacteriostatic water.
- Introduce water slowly along the glass wall. Do not fire it at the powder.
- Swirl or roll. Do not shake.
- Label mix date and concentration. Refrigerate at 2-8 C.
- Plan around 28-30 days after mixing. Discard if cloudy.
Research Cycle Pattern
Once weekly. Hold each step 4 weeks. This is the CoreVials beginner chart, not the older 2 mg trial jump.
| Phase | Weeks | Weekly amount | Units at 10 mg/mL |
|---|---|---|---|
| Start | 1-4 | 0.5 mg (or 1 mg) | 5 units (or 10) |
| Step 1 | 5-8 | 2 mg (or 1.5 mg) | 20 units (or 15) |
| Step 2 | 9-12 | 2.5 mg | 25 units |
| Step 3 | 13-16 | 3 mg | 30 units |
| Later | 17+ | +0.5 to 1 mg every 4 weeks | 5 to 10 units more |
0.5 mg is the gentler start. Stay at a hold that is still working. 12 mg is the published high end, not a starter mark.
Pairing with Cagrilintide (LEAN blend): keep this Retatrutide start, then add Cagrilintide at 0.25 mg after about 8 weeks. See the LEAN blend cheat sheet.
How This Works
GLP-1 slows the gut and quiets appetite. GIP supports insulin signaling. Glucagon raises energy use. Half-life is on the order of 6 days, so charts treat it as once weekly.
Storage and Handling
- Lyophilized: cool, dry, dark. Freeze at about -20 C for longer holding.
- After mixing: refrigerate at 2-8 C. Do not freeze. Protect from light.
- Discard cloudy or particulate solution.
Research Use Only
For educational / laboratory research reference only. Sold for laboratory research only. Not for human or animal consumption. Not medical advice.
